This is an audio version of the Wikipedia Article:
00:01:40 1 Framework
00:04:34 2 Types of aging damage and treatment schemes
00:04:45 2.1 Nuclear mutations/epimutations—OncoSENS
00:05:23 2.2 Mitochondrial mutations—MitoSENS
00:06:17 2.3 Intracellular junk—LysoSENS
00:07:10 2.4 Extracellular junk—AmyloSENS
00:07:53 2.5 Cell loss and atrophy—RepleniSENS
00:08:46 2.6 Cell senescence—ApoptoSENS
00:09:38 2.7 Extracellular crosslinks—GlycoSENS
00:10:26 3 Scientific controversy
00:13:02 3.1 iTechnology Review/i controversy
00:16:02 4 Social and economic implications
00:17:54 5 SENS meetings
00:19:55 6 SENS Research Foundation
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Speaking Rate: 0.8684926341193994
Voice name: en-AU-Wavenet-C
"I cannot teach anybody anything, I can only make them think."
Strategies for Engineered Negligible Senescence (SENS) is the term coined by British biogerontologist Aubrey de Grey for the diverse range of regenerative medical therapies, either planned or currently in development, for the periodical repair of all age-related damage to human tissue with the ultimate purpose of maintaining a state of negligible senescence in the patient, thereby postponing age-associated disease for as long as the therapies are reapplied.The term "negligible senescence" was first used in the early 1990s by professor Caleb Finch to describe organisms such as lobsters and hydras, which do not show symptoms of aging. The term "engineered negligible senescence" first appeared in print in Aubrey de Grey's 1999 book The Mitochondrial Free Radical Theory of Aging, and was later prefaced with the term "strategies" in the article Time to Talk SENS: Critiquing the Immutability of Human Aging De Grey called SENS a "goal-directed rather than curiosity-driven" approach to the science of aging, and "an effort to expand regenerative medicine into the territory of aging". To this end, SENS identifies seven categories of aging "damage" and a specific regenerative medical proposal for treating each.
While many biogerontologists find it "worthy of discussion" and SENS conferences feature important research in the field, some contend that the ultimate goals of de Grey's programme are too speculative given the current state of technology, referring to it as "fantasy rather than science".
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